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[DOI] [PubMed] [Google Scholar] 59.Khan Q.J., Reddy P.S., Kimler B.F., Sharma P., Baxa S.E., Odea A.P., Klemp J.R., Fabian C.J

In mammals, carnitine acts through the reversible esterification of its 3-hydroxyl group by fatty acyl-CoA esters with subsequent translocation of the acylcarnitines produced from one cellular compartment to another

PMID: 31617161 Biol Direct Inhibition of PRC1 elicits immunogenic cell death by triggering ROS-dependent ER stress in colorectal cancer via the Wnt/-catenin signaling pathway

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Additionally, self-derived or foreign-derived particulates can be endocytosed by lysosomes, leading to membrane damage and further release of cathepsin B, another common upstream signal for NLRP3 activation (96)

A double-blind, placebo-controlled study